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Trioxasalen

Medical Information about Trioxasalen

what is Trioxasalen?

Trioxasalen is a synthetic compound that belongs to a class of drugs called psoralens. It is used in combination with ultraviolet (UV) light therapy to treat skin conditions such as psoriasis, eczema, and vitiligo. It works by binding to the DNA in skin cells, making them more sensitive to UV light, which helps slow down the overproduction of skin cells and reduces inflammation.Trioxasalen is available in both oral and topical forms.

Trioxasalen medical uses

Trioxasalen is primarily used in combination with ultraviolet light therapy to treat skin conditions such as psoriasis, eczema, and vitiligo. It is also sometimes used to treat skin disorders caused by certain types of light sensitivity, such as cutaneous T-cell lymphoma and polymorphous light eruption. In addition, Trioxasalen has been investigated for its potential use in treating other conditions, such as diabetic foot ulcers and alopecia areata. However, its use for these conditions is not yet widespread.

How it Works Trioxasalen:

Trioxasalen, also known as trimethylpsoralen, is a photosensitizing agent used in the treatment of certain skin conditions, such as psoriasis and vitiligo. It works by binding to DNA and forming cross-links when activated by UVA radiation.

1. Activation: Trioxasalen is taken orally or applied topically to the affected area. It is inactive at this stage and needs to be activated by UVA radiation to become effective.

2. Absorption of UVA radiation: The patient is exposed to UVA radiation on the affected area of the skin. This can be done in a specialized phototherapy booth or with a hand-held UVA lamp.

3. Binding to DNA: Once activated by UVA radiation, trioxasalen binds to the DNA in the skin cells.

4. Formation of cross-links: When trioxasalen binds to the DNA, it forms cross-links between the strands of DNA. These cross-links prevent the DNA from replicating and dividing, which is necessary for the affected skin cells to grow and reproduce.

5. Suppression of immune system: The cross-linked DNA also triggers an immune response, causing the body to suppress the overactive immune system that is contributing to the skin condition.

6. Treatment: With repeated treatments, the affected areas of skin become less inflamed and symptoms such as redness, itching, and flaking are reduced. Trioxasalen has also been used in combination with other therapies, such as UVA light therapy and oral medications, to enhance the effectiveness of treatment.

It is important to follow the recommended treatment schedule and not exceed the prescribed doses, as overexposure to UVA radiation can increase the risk of skin cancer. Overall, trioxasalen works by modifying the DNA in skin cells and suppressing the immune system to treat skin conditions.

Trioxasalen Common Benefits:

Treatment of Psoriasis or Vitiligo Possibly effective for the treatment of Psoriasis or Vitiligo

Possible Side Effect(s): 

Side Effects are rare when trioxsalen is used in limited amounts

— a few minutes three or more times a week for enhanced skin pigmentation.

Trioxsalen decreases the production of white blood cells. This is beneficial for those with autoimmune diseases like psoriasis and dermatitis,

because it suppresses the over-active immune system.

Possible Side Effects:

• Redness
• painful
• sunburn-type rash
• Itchy 
• dry skin
• Unusual sensitivity to light Eye inflammation or damage
• Headache
• Nausea
• Vomiting
• Severe blistering
• and peeling (burns) Purple patches on your skin
• Changes in skin color
• Swelling 
• scaling Increased
• sweating Indigestion
• Pain during treatment Changes in result of lab tests Black stools Fever Muscular pain

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